What is Zavzpret?

Orange County Migraine & Headache Center

Zavzpret is a newly FDA approved nasal spray of Zavegepant, a CGRP receptor antagonist, and is for the acute treatment of migraine with or without aura in adults. It is in the same class as Ubrelvy and Nurtec-both oral CGRP receptor antagonists. The dose is 1 spray of 10 mg in 1 nostril in 24 hours. It may work faster than the oral CGRP receptor antagonists, also known as gepants, since it is delivered nasally. Side-effects include bad taste and nausea. It is expected to be available in pharmacies by July 2023.


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