What is Trudhesa?

Trudhesa is a nasal delivery for dihydroergotamine (DHE) and is FDA approved for the acute treatment of migraine with or without aura in adults. Features include rapid onset of action, sustained pain freedom for 48 hours, and no evidence of medication overuse headache. Drawbacks include vasoconstriction making it contraindicated for those with uncontrolled high blood pressure or coronary artery disease. It can be very effective in helping a severe or prolonged migraine attack as it reaches IV concentrations in 30 minutes. It cannot be combined with a triptan in the same 24 hours and should not be used in pregnancy.

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